Reassessing B cell contributions in multiple sclerosis
@article{Li2018ReassessingBC, title={Reassessing B cell contributions in multiple sclerosis}, author={Rui Li and Kristina R. Patterson and Amit Bar-Or}, journal={Nature Immunology}, year={2018}, volume={19}, pages={696-707} }
There is growing recognition that B cell contributions to normal immune responses extend well beyond their potential to become antibody-producing cells, including roles at the innate–adaptive interface and their potential to modulate the responses of other immune cells such as T cells and myeloid cells. These B cell functions can have both pathogenic and protective effects in the context of central nervous system (CNS) inflammation. Here, we review recent advances in the field of multiple…
206 Citations
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References
SHOWING 1-10 OF 269 REFERENCES
The Ins and Outs of B Cells in Multiple Sclerosis
- Biology, MedicineFront. Immunol.
- 2015
This review will assess the current knowledge of the mechanisms and pathways governing B cell migration into the CNS and examine evidence for and against a compartmentalized B cell response driving progressive MS pathology.
B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized Inflammation
- Biology, MedicineFront. Immunol.
- 2015
Characteristics of human B cells identified within distinct CNS subcompartments of patients with MS, including the cerebrospinal fluid, parenchymal lesions, and meninges are reviewed, as well as the relationship between B cell populations identified in these sub compartments and the periphery.
B cells and antibodies in multiple sclerosis pathogenesis and therapy
- Biology, MedicineNature Reviews Neurology
- 2012
Key features of B-cell biology, the role of B cells and antibodies in CNS inflammation, and current attempts to identify the targets of pathogenic antibodies in MS are summarized.
Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis
- Biology, MedicineFront. Immunol.
- 2016
Important antibody-independent pathogenic roles of B cells are emerging in autoimmune diseases, including multiple sclerosis (MS). The contrasting results of different treatments targeting B cells in…
Effector T Cells in Multiple Sclerosis.
- Biology, MedicineCold Spring Harbor perspectives in medicine
- 2018
Although the majority of research on MS pathogenesis has centered on the role of effector CD4 T cells, accumulating data suggests that CD8 T cells may play a significant role in the human disease.
B cell exchange across the blood-brain barrier in multiple sclerosis.
- BiologyThe Journal of clinical investigation
- 2012
Deep repertoire sequencing of IgG heavy chain variable region genes in paired cerebrospinal fluid and PB samples from patients with MS and other neurological diseases found that a restricted pool of clonally related B cells participated in robust bidirectional exchange across the BBB, suggesting that CNS-directed autoimmunity may be triggered and supported on both sides of theBBB.
Specific peripheral B cell tolerance defects in patients with multiple sclerosis.
- Medicine, BiologyThe Journal of clinical investigation
- 2013
It is demonstrated that in contrast to patients with RA or T1D, bone marrow central B cell selection in MS appears normal in most patients, and patients with MS suffer from a specific peripheral B cell tolerance defect that is potentially attributable to impaired Treg function and that leads to the accumulation of autoreactive B cell clones in their blood.
Effect of Natalizumab on Circulating CD4+ T-Cells in Multiple Sclerosis
- Biology, MedicinePloS one
- 2012
Natalizumab treatment selectively increased the effector memory T-cell pool but not the activation state of T-cells in the blood compartment and myelin-reactive T- cells in particular showed signs of increased immune activation.
Antibody-independent functions of B cells: a focus on cytokines
- Biology, MedicineNature Reviews Immunology
- 2015
B cells can regulate inflammatory immune responses, primarily through their provision of IL-10 and IL-35, and the rational for targeting these cells in the clinic is discussed.
B cells regulate autoimmunity by provision of IL-10
- Biology, MedicineNature Immunology
- 2002
Data show that B cell–derived IL-10 plays a key role in controlling autoimmunity and that recovery was dependent on the presence of autoantigen-reactive B cells.