Reassembly of shattered chromosomes in Deinococcus radiodurans

@article{Zahradka2006ReassemblyOS,
  title={Reassembly of shattered chromosomes in Deinococcus radiodurans},
  author={Ksenija Zahradka and Dea Slade and Adriana Bailone and Suzanne Sommer and Dietrich Averbeck and Mirjana Petranovi{\'c} and Ariel B. Lindner and Miroslav Radman},
  journal={Nature},
  year={2006},
  volume={443},
  pages={569-573}
}
Dehydration or desiccation is one of the most frequent and severe challenges to living cells. The bacterium Deinococcus radiodurans is the best known extremophile among the few organisms that can survive extremely high exposures to desiccation and ionizing radiation, which shatter its genome into hundreds of short DNA fragments. Remarkably, these fragments are readily reassembled into a functional 3.28-megabase genome. Here we describe the relevant two-stage DNA repair process, which involves a… CONTINUE READING
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