Reasons for the occurrence of the twenty coded protein amino acids

@article{Weber1981ReasonsFT,
  title={Reasons for the occurrence of the twenty coded protein amino acids},
  author={Arthur L. Weber and Stanley L. Miller},
  journal={Journal of Molecular Evolution},
  year={1981},
  volume={17},
  pages={273-284}
}
Factors involved in the selection of the 20 protein L-α-amino acids during chemical evolution and the early stages of Darwinian evolution are discussed. The selection is considered on the basis of the availability in the primitive ocean, function in proteins, the stability of the amino acid and its peptides, stability to racemization, and stability on the transfer RNA. We conclude that aspartic acid, glutamic acid, arginine, lysine, serine and possibly threonine are the best choices for acidic… CONTINUE READING

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