Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

@article{Palanisamy2010RearrangementsOT,
  title={Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma},
  author={Nallasivam Palanisamy and Bushra Ateeq and Shanker Kalyana-Sundaram and Dorothee Pflueger and Kalpana Ramnarayanan and Sunita Shankar and Bo Han and Qi Cao and Xuhong Cao and Khalid Suleman and Chandan Kumar-Sinha and Saravana M. Dhanasekaran and Ying-Bei Chen and Raquel Esgueva and Samprit Banerjee and Christopher J Lafargue and Javed Ather Siddiqui and Francesca Demichelis and Peter Moeller and Tarek A. Bismar and Rainer Kuefer and Douglas Randall Fullen and Timothy M. Johnson and Joel K. Greenson and Thomas J. Giordano and Patrick Tan and Scott Arthur Tomlins and Sooryanarayana Varambally and Mark A. Rubin and Christopher A. Maher and Arul M. Chinnaiyan},
  journal={Nature Medicine},
  year={2010},
  volume={16},
  pages={793-798}
}
Although recurrent gene fusions involving erythroblastosis virus E26 transformation-specific (ETS) family transcription factors are common in prostate cancer, their products are considered 'undruggable' by conventional approaches. Recently, rare targetable gene fusions involving the anaplastic lymphoma receptor tyrosine kinase (ALK) gene, have been identified in 1–5% of lung cancers, suggesting that similar rare gene fusions may occur in other common epithelial cancers, including prostate… CONTINUE READING

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