Rearrangements of immunoglobulin and T cell receptor beta and gamma genes are associated with terminal deoxynucleotidyl transferase expression in acute myeloid leukemia

Abstract

The cell origin of the rare terminal deoxynucleotidyl transferase (TdT)-positive acute myeloid leukemias (AML) was investigated at the molecular level, by examining the configuration of the Ig H (Igh) and L (Ig kappa, Ig lambda) chain gene regions, and of the T cell receptor (TCR) beta and T cell rearranging (TRG) gamma loci. In 8 of the 10 TdT+ AML… (More)

Topics

3 Figures and Tables

Cite this paper

@article{Fo1987RearrangementsOI, title={Rearrangements of immunoglobulin and T cell receptor beta and gamma genes are associated with terminal deoxynucleotidyl transferase expression in acute myeloid leukemia}, author={Robin Fo{\'a} and Giulia Casorati and M C Giubellino and Giuseppe Basso and Rafaella Schiro and Giovanni Pizzolo and Francesco Nicola Lauria and Marie-Paule Lefranc and Terence H. Rabbitts and Nicola Migone}, journal={The Journal of Experimental Medicine}, year={1987}, volume={165}, pages={879 - 890} }