Rearrangements of MYC gene facilitate risk stratification in diffuse large B-cell lymphoma patients treated with rituximab-CHOP

@article{Tzankov2014RearrangementsOM,
  title={Rearrangements of MYC gene facilitate risk stratification in diffuse large B-cell lymphoma patients treated with rituximab-CHOP},
  author={Alexandar Tzankov and Zijun Y. Xu-Monette and Marc Gerhard and Carlo Visco and Stephan R Dirnhofer and Nora Gisin and Karen Dybkaer and Attilio Orazi and Govind Bhagat and Kristy L Richards and E D Hsi and William W L Choi and Johan H. J. M. van Krieken and Maurilio Ponzoni and Andr{\'e}s J M Ferreri and Qing Ye and Jane N. Winter and John P. Farnen and Miguel {\'A}ngel Piris and Michael Boe M\oller and Mingjian James You and T. J. McDonnell and L Jeffrey Medeiros and KEN. H. YOUNG},
  journal={Modern Pathology},
  year={2014},
  volume={27},
  pages={958-971}
}
In order to address the debatable prognostic role of MYC rearrangements in diffuse large B-cell lymphoma patients treated with rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone, we evaluated MYC rearrangements by fluorescence in situ hybridization in 563 cases using break-apart probes and IGH/MYC dual-fusion probes. Concurrent BCL2 and BCL6 aberrations were also assessed. Data were correlated with clinicopathological variables and prognostic parameters. MYC… CONTINUE READING
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MYC/BCL2 protein co-expression associated with high-risk gene signatures contributes to the inferior prognosis of activated B-cell subtype of DLBCL

  • S Hu, ZY Xu-Monette, A Tzankov
  • Blood
  • 2013

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