Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemic cell differentiation.

@article{Chen1991RearrangementsIT,
  title={Rearrangements in the second intron of the RARA gene are present in a large majority of patients with acute promyelocytic leukemia and are used as molecular marker for retinoic acid-induced leukemic cell differentiation.},
  author={Shun-le Chen and Yuelin Jack Zhu and Joanna Hung-Man Tong and Shaozhong Dong and W Huang and Yvonne Chen and Wei Xiang and Leanne Zhang and Xiujiang Susie Li and Geng-sun Qian},
  journal={Blood},
  year={1991},
  volume={78 10},
  pages={2696-701}
}
Chromosome 17 breakpoints in translocation t(15;17), a hallmark for acute promyelocytic leukemia (APL), have been shown to disrupt the retinoic acid receptor-alpha (RARA) gene. In this study, DNA probes around the second exon of the RARA gene showed rearrangements not previously detected. Analysis of 25 Chinese APL cases showed that RARA gene rearrangements were present in 23 cases (92%). The breakpoints were mapped unequivocally in 22 cases within the second intron of the gene. Therefore, the… CONTINUE READING

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