Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma.

  title={Rearrangements and increased expression of cyclin D1 (CCND1) in neuroblastoma.},
  author={Jan J. Molenaar and Peter G van Sluis and Kathy Boon and Rogier Versteeg and H. N. Caron},
  journal={Genes, chromosomes & cancer},
  volume={36 3},
Cyclin D1 regulates G1 cell cycle progression by controlling the phosphorylation of the retinoblastoma protein. This pathway is frequently deregulated in many malignancies. In neuroblastoma, however, no consistent G1 cell cycle checkpoint aberrations have been found. We examined the possible deregulation of cyclin D1 (CCND1) in this tumor. mRNA expression profiles of neuroblastoma generated by SAGE (Serial Analysis of Gene Expression) revealed a high expression of CCND1 in a subset of… CONTINUE READING


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