Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice

Immunoglobulin (Ig) and T-cell antigen receptor genes rearrange through identical heptamer–nonamer recognition sequences during entry of cells into the B or T lymphoid lineage1–5. A similar enzymatic machinery may be used to perform these highly cell-specific events in these two types of lymphoid cells6. We have investigated what the signal may be that… CONTINUE READING