Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma.

  title={Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma.},
  author={Wolfram G. Scheurlen and Armin Stremlau and Lutz Gissmann and D H H{\"o}hn and Hans Peter Zenner and Harald zur Hausen},
  journal={International journal of cancer},
  volume={38 5},
By hybridization under stringent conditions, one out of two anal carcinomas and one out of 36 laryngeal carcinomas were shown to harbor HPV 16 DNA in high copy number. Further analysis of both tumor DNAs indicated a rearrangement of the viral DNA in the tumor cells. HPV 16 DNA in the anal carcinoma could chiefly be found episomally in two different forms: a minority as 7.9-kb oligomeric episomes with no apparent modifications; as 10.7-kb rear-ranged oligomeric episomes with a duplication of the… CONTINUE READING