Reappraising striatal D1- and D2-neurons in reward and aversion

@article{SoaresCunha2016ReappraisingSD,
  title={Reappraising striatal D1- and D2-neurons in reward and aversion},
  author={Carina Soares-Cunha and B{\'a}rbara Coimbra and Nuno Sousa and Ana Jo{\~a}o Rodrigues},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2016},
  volume={68},
  pages={370-386}
}
The striatum has been involved in complex behaviors such as motor control, learning, decision-making, reward and aversion. The striatum is mainly composed of medium spiny neurons (MSNs), typically divided into those expressing dopamine receptor D1, forming the so-called direct pathway, and those expressing D2 receptor (indirect pathway). For decades it has been proposed that these two populations exhibit opposing control over motor output, and recently, the same dichotomy has been proposed for… Expand
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