Reappraisal with meta-analysis of the addition of Gram-positive prophylaxis to fluoroquinolone in neutropenic patients.

@article{Cruciani2003ReappraisalWM,
  title={Reappraisal with meta-analysis of the addition of Gram-positive prophylaxis to fluoroquinolone in neutropenic patients.},
  author={Mario Cruciani and Marina Malena and Oliviero Bosco and Stefano Nardi and Giovanni Serpelloni and Carlo Mengoli},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2003},
  volume={21 22},
  pages={4127-37}
}
PURPOSE Past reports and meta-analyses indicate that fluoroquinolones are highly effective in preventing Gram-negative infections in neutropenic cancer patients, but offer inadequate coverage for Gram-positive infections. We evaluated by meta-analysis the efficacy of the addition of antimicrobial agents with enhanced Gram-positive activity to prophylaxis with quinolones. MATERIALS AND METHODS Randomized trials comparing fluoroquinolones alone (ciprofloxacin, ofloxacin, pefloxacin, or… CONTINUE READING