Reappraisal of the serotonin 5-HT(1B) receptor gene in alcoholism: of mice and men.

@article{Gorwood2002ReappraisalOT,
  title={Reappraisal of the serotonin 5-HT(1B) receptor gene in alcoholism: of mice and men.},
  author={Philip Gorwood and Franck Aissi and Philippe Batel and Jean Ad{\`e}s and Charles Cohen-Salmon and Michel Hamon and Claudette Boni and Laurence Lanfumey},
  journal={Brain research bulletin},
  year={2002},
  volume={57 1},
  pages={103-7}
}
Because pharmacological and genetic data supported the idea that serotonin receptors of the 5-HT(1B) type can play a modulatory role in alcohol consumption in both human and rodents, the 5-HT(1B) receptor gene is considered as a candidate gene for alcohol dependence. However, contradictory results have been reported as a positive association between alcohol dependence, and either the 861C or the 861G allele of the G861C polymorphism of the 5-HT(1B) receptor gene can be found in the literature… CONTINUE READING