Hansemann, Boveri, chromosomes and the gametogenesis‐related theories of tumours
- BiologyCell biology international
Cellular and molecular pathology of adrenocortical carcinoma
- Biology, Medicine
This chapter will focus on the contributions of other known or suggested pathways, genomic and genetic alterations, as well as common principles of carcinogenesis, such as aneuploidy and clonal origin.
Integrating Conflicting Cancer Theories by Recognizing the Roles of Epigenetic and Genetic Alterations in the Immediate-Cancer-Causing Genes that Establish Cellular Immortality and Autonomy
The integrated theory describes that any extracellular, intracellular, or intranuclear stressors can initiate a lengthy tumorigenesis to engender a benign or malignant tumor, but the aberrations directly establishing cellular immortality and autonomy may be epigenetic or genetic alterations in the genomic DNA.
Aneuploidy as a promoter and suppressor of malignant growth
- Biology, MedicineNature reviews. Cancer
The diverse facets of cancer biology that are shaped by aneuploidy are discussed, including metastasis, drug resistance and immune recognition, and aneuPLoidy’s distinct roles as both a tumour promoter and an anticancer vulnerability are highlighted.
Mechanisms and Consequences of Chromosomal Instability in Malignant tumours
- Medicine, Biology
The results indicate that telomere dependent chromosomal instability is present in both colorectal cancer andWilms tumour and could be an important prognostic factor in Wilms tumours.
The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer
The hypothesis that the disruption of trace element homeostasis and the phenomenon of aneuploidy might be linked with the cancer-promoting role of point mutations and focal copy number alterations in established tumor suppressor genes and oncogenes is discussed.
New insights into the troubles of aneuploidy.
- BiologyAnnual review of cell and developmental biology
The detrimental, potentially beneficial, and sometimes puzzling effects of aneuploidy on cellular and organismal fitness and tissue function as well as its role in diseases such as cancer and neurodegeneration are discussed.
Neosis - A Parasexual Somatic Reduction Division in Cancer
Neosis paradigm supports the concept that cancer arises via neosis, cancer cells are not immortal, but undergo repeated senescent phases and that tumor cell lineage continuity is due to escape from senescent phase via neOS, since tumor cells carry mutant or epimutant genes in the senescent checkpoint pathway.
The Janus soul of centrosomes: a paradoxical role in disease?
- BiologyChromosome Research
The origins and the consequences of centrosome flaws are discussed, with particular attention on how they contribute to developmental diseases.
Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution☆
- BiologyApplied & translational genomics
SHOWING 1-10 OF 112 REFERENCES
hCDC4 and Genetic Instability in Cancer
- BiologyCell cycle
The assertion that a genetic basis for aneuploidy would imply its importance in tumorigenesis, and consequently make it a potential therapeutic target, represents the rationale for the pursuit of this line of research.
Aneuploidy and cancer
- BiologyCurrent opinion in oncology
Three lines of evidence now make a compelling case for aneuploidy being a discrete chromosome mutation event that contributes to malignant transformation and progression process, and genes implicated in regulating chromosome segregation found mutated in cancer cells are discussed.
Aneuploidy versus gene mutation as cause of cancer
The aneuploidy hypothesis explains the exceedingly long latent periods, years to decades, between carcinogen and carcinogenesis, and catalyzes karyotype evolution that eventually generates carcinogenic karyotypes.
A tentative classification of centrosome abnormalities in cancer
- BiologyCell biology international
The Chromosomes in Human Cancer and Leukemia
- Biology, Medicine
The past decade has witnessed significant advances in some aspects of cancer biology, especially the genetic changes in cancer cells, and the karyotypic picture of any particular tumor has become of value to clinicians, biologists, and clinicians.
Centrosome defects and genetic instability in malignant tumors.
- BiologyCancer research
Centrosomes in nearly all tumors and tumor-derived cell lines were atypical in shape, size, and composition and were often present in multiple copies, suggesting they may contribute to genetic instability in cancer.
Imbalance of morphologically addressed telophases reflects interphase DNA aneuploidy in tumorigenesis.
- Medicine, BiologyEuropean journal of histochemistry : EJH
Chromosome division figures (CDFs) are quantitatively different from normal mitoses and represent a novel cytogenetic phenomenon. This investigation was focused on morphologically addressed bipolar…
The role of chromosomal instability in tumor initiation
- BiologyProceedings of the National Academy of Sciences of the United States of America
The conditions for CIN to initiate the process of colorectal tumorigenesis before the inactivation of tumor suppressor genes are calculated.
Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres
- Biology, MedicineBritish Journal of Cancer
Evaluated cell division dynamics in low-passage cell lines from three benign and five malignant head and neck tumours revealed a strong positive correlation between multipolarity of the mitotic spindle and the formation of bridges at anaphase in both benign and malignant tumours.
Catalog of Chromosome Aberrations in Cancer
- MedicineBritish Journal of Cancer
The fifth edition of Mitelman's catalogue provides a staggering collection of karyotypes from more than 22 000 individual neoplasms, drawn from all over the world, and describes every karyotype according to the most recent terminology, namely the International System for Cytogenetic Nomenclature 1991.