Reappraisal of the Hansemann—Boveri hypothesis on the origin of tumors

@article{Hardy2005ReappraisalOT,
  title={Reappraisal of the Hansemann—Boveri hypothesis on the origin of tumors},
  author={Paul A. Hardy and Helmut Zacharias},
  journal={Cell Biology International},
  year={2005},
  volume={29}
}
Cancer is now known to be a genetic disease. In tumor development, cell nuclei undergo mutations, which can result in cytologically visible chromosome aberrations. The aneuploid errors may involve amplification or deletion of whole chromosomes or segments thereof. David Hansemann [1858–1920] and Theodor Boveri [1862–1915] were major contributors to early debates on the relationship between chromosomal defects, tumorigenesis and malignancies. In 1890, Hansemann observed asymmetrical nuclear… 
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References

SHOWING 1-10 OF 112 REFERENCES
hCDC4 and Genetic Instability in Cancer
TLDR
The assertion that a genetic basis for aneuploidy would imply its importance in tumorigenesis, and consequently make it a potential therapeutic target, represents the rationale for the pursuit of this line of research.
Aneuploidy and cancer
  • Subrata Sen
  • Medicine
    Current opinion in oncology
  • 2000
TLDR
Three lines of evidence now make a compelling case for aneuploidy being a discrete chromosome mutation event that contributes to malignant transformation and progression process, and genes implicated in regulating chromosome segregation found mutated in cancer cells are discussed.
Aneuploidy versus gene mutation as cause of cancer
TLDR
The aneuploidy hypothesis explains the exceedingly long latent periods, years to decades, between carcinogen and carcinogenesis, and catalyzes karyotype evolution that eventually generates carcinogenic karyotypes.
A tentative classification of centrosome abnormalities in cancer
  • S. Duensing
  • Biology, Medicine
    Cell biology international
  • 2005
TLDR
This review proposes to classify centrosome abnormalities in tumor cells into three groups based on their relevance to genomic instability: primaryCentrosome overduplication, transient centrosomes accumulation, and permanent centrosom accumulation.
The Chromosomes in Human Cancer and Leukemia
TLDR
The past decade has witnessed significant advances in some aspects of cancer biology, especially the genetic changes in cancer cells, and the karyotypic picture of any particular tumor has become of value to clinicians, biologists, and clinicians.
Centrosome defects and genetic instability in malignant tumors.
TLDR
Centrosomes in nearly all tumors and tumor-derived cell lines were atypical in shape, size, and composition and were often present in multiple copies, suggesting they may contribute to genetic instability in cancer.
Imbalance of morphologically addressed telophases reflects interphase DNA aneuploidy in tumorigenesis.
  • R. Steinbeck
  • Biology, Medicine
    European journal of histochemistry : EJH
  • 1997
Chromosome division figures (CDFs) are quantitatively different from normal mitoses and represent a novel cytogenetic phenomenon. This investigation was focused on morphologically addressed bipolar
The role of chromosomal instability in tumor initiation
TLDR
The conditions for CIN to initiate the process of colorectal tumorigenesis before the inactivation of tumor suppressor genes are calculated.
Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres
TLDR
Evaluated cell division dynamics in low-passage cell lines from three benign and five malignant head and neck tumours revealed a strong positive correlation between multipolarity of the mitotic spindle and the formation of bridges at anaphase in both benign and malignant tumours.
Catalog of Chromosome Aberrations in Cancer
TLDR
The fifth edition of Mitelman's catalogue provides a staggering collection of karyotypes from more than 22 000 individual neoplasms, drawn from all over the world, and describes every karyotype according to the most recent terminology, namely the International System for Cytogenetic Nomenclature 1991.
...
1
2
3
4
5
...