Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis.

@article{Kayser2012ReappraisalOA,
  title={Reappraisal of acetazolamide for the prevention of acute mountain sickness: a systematic review and meta-analysis.},
  author={Bengt Kayser and Lionel Dumont and Christopher Lysakowski and Christophe Combescure and Guy Haller and Martin R. Tram{\`e}r},
  journal={High altitude medicine & biology},
  year={2012},
  volume={13 2},
  pages={
          82-92
        }
}
Acetazolamide is used to prevent acute mountain sickness (AMS). We assessed efficacy and harm of acetazolamide for the prevention of AMS, and tested for dose-responsiveness. We systematically searched electronic databases (until April 2011) for randomized trials comparing acetazolamide with placebo for the prevention of AMS. For each dose, risk ratios were aggregated using a Mantel-Haenszel fixed effect model. Numbers needed to treat (NNT) to benefit one subject with each dose were calculated… CONTINUE READING

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