Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity.

@article{Thress1999ReaperinducedDO,
  title={Reaper-induced dissociation of a Scythe-sequestered cytochrome c-releasing activity.},
  author={Ken Thress and Erica K. Evans and Sally Kornbluth},
  journal={The EMBO journal},
  year={1999},
  volume={18 20},
  pages={
          5486-93
        }
}
Reaper is a potent apoptotic inducer critical for programmed cell death in the fly Drosophila melanogaster. While Reaper homologs from other species have not yet been reported, ectopic expression of Reaper in cells of vertebrate origin can also trigger apoptosis, suggesting that Reaper-responsive pathways are likely to be conserved. We recently reported that Reaper-induced mitochondrial cytochrome c release and caspase activation in a cell-free extract of Xenopus eggs requires the presence of a… CONTINUE READING

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