Reanalysis of the first case of Alzheimer’s disease

@article{Graeber1999ReanalysisOT,
  title={Reanalysis of the first case of Alzheimer’s disease},
  author={Manuel B. Graeber and Parviz Mehraein},
  journal={European Archives of Psychiatry and Clinical Neuroscience},
  year={1999},
  volume={249},
  pages={S10-S13}
}
  • M. Graeber, P. Mehraein
  • Published 15 December 1999
  • Biology
  • European Archives of Psychiatry and Clinical Neuroscience
Abstract When a disease becomes as important as Alzheimer’s dementia, there is a natural interest in its medical history and in the origin of the underlying disease concept. Key to understanding Alois Alzheimer’s views on the disease, which was named after him, are the histological sections of the cases he saw. This histological material was rediscovered in Munich in 1992 and 1997 (Neurogenetics 1997, 1 : 73-80; 1998, 1 : 223-228). An extensive neuropathological and molecular genetic analysis… 
Alzheimer's 100th anniversary of death and his contribution to a better understanding of Senile dementia.
TLDR
Alois Alzheimer's examination of Auguste D's case, studied by him with Bielschowsky's silver impregnation technique, permitted to identify a pathological marker, the intraneuronal neurofibrillary tangles, characterizing a new disease later named after him - Alzheimer's disease.
Molecular Pathology of Alzheimer's Disease
TLDR
This book details the discovery of metabolic cascades involving amyloid-β production in the case of the senile plaque, and phosphorylated-tau protein in the cases of the neurofibrillary tangle in Alzheimer’s Disease.
[Alzheimer and Alzheimer's disease: the present enlighted by the past. An historical approach].
  • C. Derouesné
  • Psychology
    Psychologie & neuropsychiatrie du vieillissement
  • 2008
TLDR
Beyond the description of the disease termed by his name, Alzheimer's work played a major role in the individualization of arteriosclerotic dementia from general palsy, and in the distinction between vascular and degenerative dementia.
Cajal's contributions to the study of Alzheimer's disease.
TLDR
This paper deals with Cjal's contribution to the study of Alzheimer's disease and it is fully illustrated by original pictures of Cajal's slides preserved in the Cajals Museum, Madrid.
Alzheimer's Memory
Alois Alzheimer (1864 ^ 1915; figure 1) published his paper describing the abnormalities in the brain cells of his patient, Auguste D, one hundred years ago (Alzheimer 1907). The substance of
Alzheimer 100 – highlights in the history of Alzheimer research
Summary.Alzheimer disease, a progressive neurodegenerative disorder of hitherto unknown etiology leading progressively to severe incapacity and death, has become the pandemic of the 21st century. On
Alzheimer's disease: Cholesterol a menace?
New Findings, New Thinking, and New Expectations in Alzheimer's Disease
TLDR
This issue of CNS Spectrums focuses on the shift in thinking about AD, and Hillel Grossman, MD, expands the paradigm shift by focusing on diabetes mellitus and its relationship to AD.
History as a biomedical matter: recent reassessments of the first cases of Alzheimer’s disease
  • Lara Keuck
  • Sociology
    History and philosophy of the life sciences
  • 2017
TLDR
How the various ways of using and understanding ‘history’ were put forward to re-present historic cases as ‘proto-types’ for studying Alzheimer’s disease in the present is analyzed.
...
...

References

SHOWING 1-10 OF 25 REFERENCES
Histopathology and APOE genotype of the first Alzheimer disease patient, Auguste D.
TLDR
The histopathology and APOE genotype of Alois Alzheimer's first patient, Auguste D., marks the beginning of research into Alzheimer disease, and neurofibrillary tangles were first described in this brain.
The case described by Alois Alzheimer in 1911
TLDR
A careful analysis of all pros and contras in the literature led to the conclusion that plaque-only cases are also an integrative part of the modern Alzheimer disease concept.
Rediscovery of the case described by Alois Alzheimer in 1911: historical, histological and molecular genetic analysis
TLDR
This case is of historical importance as it may have convinced Kraepelin to name the disease after his co-worker, Alois Alzheimer, and it was shown to be homozygous for apolipoprotein allele ε3 and lacked APP mutations at codons 692, 693, 713 and 717.
Auguste D. and Alzheimer's Disease
TLDR
It now appears that Auguste D.'s dementia may have been at least partly caused, not by the typical neurodegeneration of Alzheimer's, but by arteriosclerosis of the brain.
No Man Alone: The Rediscovery of Alois Alzheimer's Original Cases
TLDR
The present article summarizes the unusual history of this rediscovery of Alzheimer's cases in Munich and illustrates the great value of international exchange in science.
The first Alzheimer disease case: a metachromatic leukodystrophy?
TLDR
The histopathology of this first case shows some features that are not characteristic of the histological pattern of the modern Alzheimer, namely demyelination of the central white matter and metachromatic deposits in the spinal cord.
Alzheimer's original patient.
TLDR
It is concluded that Alzheimer's patient could have had a late form of metachromatic leukodystrophy, where plaques and tangles are also present—not an Alzheimer's case then, but certainly an “Alzheimer's pathology”.
First Alzheimer's Diagnosis Confirmed
TLDR
German scientists have uncovered a piece of science history: brain samples from Auguste D., the first Alzheimer9s patient ever to be described in medical literature, likely to put an end to lingering doubts about the cause of Auguste9s dementia.
über eigenartige Krankheitsfälle des späteren Alters
TLDR
A case of disease of the presenium which during life presented features different from those of recognized diseases and which on microscopic examination showed alterations of the cerebral cortex that were then unknown, which could not be categorized among known disorders.
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
TLDR
A minimal cosegregating region containing the AD3 gene is defined, and at least 19 different transcripts encoded within this region corresponds to a novel gene whose product is predicted to contain multiple transmembrane domains and resembles an integral membrane protein.
...
...