Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis.

  title={Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis.},
  author={Norbert Schuff and William D. Rooney and Robert H. Miller and Deborah F. Gelinas and Diane L Amend and Andrew A. Maudsley and Michael W Weiner},
  journal={Magnetic resonance in medicine},
  volume={45 3},
The goal of this work was to reexamine previously published (1) brain spectroscopy data of abnormal metabolite ratios in amyotrophic lateral sclerosis (ALS). Toward this goal, (1)H MR spectroscopic imaging data from 10 ALS and nine control subjects were reanalyzed using improved data analysis techniques, including automated curve fitting and tissue-volume correction. In the motor cortex of ALS, N-acetyl aspartate (NAA) was 23% (P = 0.004) lower than in controls, and in the posterior internal… CONTINUE READING