Realities of high-throughput liquid chromatography/mass spectrometry purification of large combinatorial libraries: a report on overall sample throughput using parallel purification.

@article{Isbell2002RealitiesOH,
  title={Realities of high-throughput liquid chromatography/mass spectrometry purification of large combinatorial libraries: a report on overall sample throughput using parallel purification.},
  author={J. Isbell and R. Xu and Z. Cai and D. Kassel},
  journal={Journal of combinatorial chemistry},
  year={2002},
  volume={4 6},
  pages={
          600-11
        }
}
We report on the development of a validated, streamlined high-throughput process for the purification of parallel-synthesis-derived combinatorial libraries. The steps involved in this library purification process include dissolution of dry films of crude synthetic material, dual-column LC/MS purification, dual-column postpurification analysis, quantitation, reformatting, and submission of pure compounds for registration. Although the purification and postpurification analysis times decreased… Expand
High-Throughput Purification
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