Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice

@article{Oleson2009RealtimeVD,
  title={Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice},
  author={Erik B. Oleson and Jonathan Salek and Keith Bonin and Sara R Jones and Evgeny A. Budygin},
  journal={Neuroscience Letters},
  year={2009},
  volume={467},
  pages={144-146}
}
In the present voltammetric study, we have characterized cocaine-induced changes in evoked dopamine release and uptake in the striatum of freely moving mice in real time. Cocaine induced marked dopamine uptake inhibition measured as apparent K(m) changes, producing a maximal effect 20min following a single injection (15mg/kg, i.p.). Changes in uptake were paralleled by increases in evoked dopamine release per stimulus pulse, revealing a high correlation between these two parameters following… CONTINUE READING

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