Real-time restoration of white-light confocal microscope optical sections

  title={Real-time restoration of white-light confocal microscope optical sections},
  author={Madhusudhanan Balasubramanian and S. Sitharama Iyengar and Roger W. Beuerman and Juan Reynaud and Peter R. Wolenski},
  journal={Journal of electronic imaging},
  volume={16 3},
Confocal microscopes (CM) are routinely used for building 3-D images of microscopic structures. Nonideal imaging conditions in a white-light CM introduce additive noise and blur. The optical section images need to be restored prior to quantitative analysis. We present an adaptive noise filtering technique using Karhunen-Loéve expansion (KLE) by the method of snapshots and a ringing metric to quantify the ringing artifacts introduced in the images restored at various iterations of iterative Lucy… CONTINUE READING


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