Real-time prediction of hand trajectory by ensembles of cortical neurons in primates

@article{Wessberg2000RealtimePO,
  title={Real-time prediction of hand trajectory by ensembles of cortical neurons in primates},
  author={Johan Wessberg and Christopher R. Stambaugh and Jerald D. Kralik and Pamela D. Beck and Mark Laubach and John K. Chapin and Jung Kim and S. James Biggs and Mandayam A. Srinivasan and Miguel A. L. Nicolelis},
  journal={Nature},
  year={2000},
  volume={408},
  pages={361-365}
}
Signals derived from the rat motor cortex can be used for controlling one-dimensional movements of a robot arm. It remains unknown, however, whether real-time processing of cortical signals can be employed to reproduce, in a robotic device, the kind of complex arm movements used by primates to reach objects in space. Here we recorded the simultaneous activity of large populations of neurons, distributed in the premotor, primary motor and posterior parietal cortical areas, as non-human primates… 

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References

SHOWING 1-10 OF 85 REFERENCES

Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex

TLDR
A possible means for movement restoration in paralysis patients is suggested after rats trained to position a robot arm to obtain water by pressing a lever routinely used brain-derived signals to position the robot arm and obtain water.

Cortical ensemble activity increasingly predicts behaviour outcomes during learning of a motor task

TLDR
Ch chronically recording from neuronal ensembles located in the rat motor cortex, throughout the period required for rats to learn a reaction-time task demonstrated a decrease in the variance of the rats' reaction times and an increase in the time the animals were able to wait for a trigger stimulus.

Neuronal population coding of movement direction.

TLDR
The direction of movement was found to be uniquely predicted by the action of a population of motor cortical neurons that can be monitored during various tasks, and similar measures in other neuronal populations could be of heuristic value where there is a neural representation of variables with vectorial attributes.

On the relations between the direction of two-dimensional arm movements and cell discharge in primate motor cortex

TLDR
The orderly variation of cell discharge with the direction of movement and the fact that cells related to only one of the eight directions of movement tested were rarely observed indicate that movements in a particular direction are not subserved by motor cortical cells uniquely related to that movement.

Predicting Measures of Motor Performance from Multiple Cortical Spike Trains

TLDR
The results suggest that hypotheses concerning the response variables "controlled" by cortical motor systems may well depend upon whether or not the temporal relations between simultaneously active neurons are taken into account.

Direct cortical representation of drawing.

TLDR
A population vector method was used to visualize the motor cortical representation of the hand's trajectory made by rhesus monkeys as they drew spirals and showed that the movement trajectory is an important determinant of motor cortical activity.

Posterior parietal association cortex of the monkey: command functions for operations within extrapersonal space.

TLDR
A large proportion of area 5 neurons were relatively insensitive to passive joint rotations, as compared with similar neurons of the postcentral gyrus, but were driven to high rates of discharge when the same joint was rotated during an active movement of the animal.

Postspike facilitation of forelimb muscle activity by primate corticomotoneuronal cells.

TLDR
In macaque monkeys making rampand-hold wrist movements against elastic loads, activity of task-related motor cortex cells and specific wrist and finger muscles was recorded and postspike facilitation (PSF) of average EMG activity was recorded.

Combination of hand and gaze signals during reaching: activity in parietal area 7 m of the monkey.

TLDR
This area seems to perform an early combination of information in the processing leading from target localization to movement generation, and for the majority of cells to a combination of visuomanual and oculomotor information.

Do neurons in the motor cortex encode movement direction? An alternative hypothesis

...