Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system.

@article{Kuo2012RealtimePI,
  title={Real-time photoacoustic imaging of prostate brachytherapy seeds using a clinical ultrasound system.},
  author={Nathanael Kuo and Hyun-Jae Kang and Danny Y. Song and Jin U. Kang and Emad Boctor},
  journal={Journal of biomedical optics},
  year={2012},
  volume={17 6},
  pages={
          066005
        }
}
Prostate brachytherapy is a popular prostate cancer treatment option that involves the permanent implantation of radioactive seeds into the prostate. However, contemporary brachytherapy procedure is limited by the lack of an imaging system that can provide real-time seed-position feedback. While many other imaging systems have been proposed, photoacoustic imaging has emerged as a potential ideal modality to address this need, since it could easily be incorporated into the current ultrasound… 
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33 Citations
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Methods Citations
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33 Citations

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Citation Type

Improving photoacoustic imaging contrast of brachytherapy seeds
TLDR
To improve imaging contrast and depth penetration, absorption enhancing coating is applied to the seeds and it is demonstrated that the coating of the Seeds can further improve the discernibility of the seeds.
In vivo photoacoustic imaging of prostate brachytherapy seeds
TLDR
In vivo limitations with insufficient light delivery within the ANSI laser safety limit (100 mJ/cm2) were overcome by utilizing a short-lag spatial coherence (SLSC) beamformer, which provided average seed contrasts of 20-30 dB for energy densities ranging 8-84 mJ /cm2.
Coherence-based photoacoustic imaging of brachytherapy seeds implanted in a canine prostate
TLDR
Results indicate that advanced methods, such as SLSC beamforming or frequency-based filters, hold promise for intraoperative localization of prostate brachytherapy seeds.
In vivo visualization of prostate brachytherapy seeds with photoacoustic imaging
TLDR
A canine study to investigate the in vivo feasibility of photoacoustic imaging for intraoperative updates to brachytherapy treatment plans finds signal-to-noise ratios (SNRs) were similar while the contrast-to thenoise ratio (CNR) was higher in SLSC compared to DAS images.
Transurethral light delivery for prostate photoacoustic imaging
TLDR
The proposed light delivery and beamforming methods promise to improve key prostate cancer detection and treatment strategies.
Short-lag spatial coherence beamforming of photoacoustic images for enhanced visualization of prostate brachytherapy seeds.
TLDR
Results indicate that the SLSC beamformer has potential to enhance the visualization of prostate brachytherapy seeds that are distant from the light source.
Photoacoustic imaging of prostate brachytherapy seeds with transurethral light delivery
TLDR
This work is the first to demonstrate the feasibility of photoacoustic imaging of prostate brachytherapy seeds using a transurethral light delivery method.
An image-guidance system for dynamic dose calculation in prostate brachytherapy using ultrasound and fluoroscopy.
TLDR
The proposed image-guidance system is the first practical approach to dynamic dose calculation, outperforming earlier solutions in terms of robustness, ease of use, and functional completeness.
Laser Illumination Modality of Photoacoustic Imaging Technique for Prostate Cancer
TLDR
In order to make a comparison of different laser illumination modality of photoacoustic imaging technique for prostate cancer, optical model of human prostate was established and combined with Monte Carlo simulation method to calculate the light absorption distribution in the prostate tissue.
Photoacoustic clinical imaging
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References

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TLDR
The latest efforts of localizing prostate brachytherapy seeds using photoacoustic imaging, including visualization of multiple seeds in actual prostate tissue are demonstrated.
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TLDR
It is found that photoacoustic imaging at 1064 nm can identify brachytherapy seeds uniquely at laser penetration depths of 5 cm in biological tissue at the ANSI limit for human exposure with a contrast-to-noise ratio of 26.5 dB.
Photoacoustic imaging of prostate brachytherapy seeds
Brachytherapy seed therapy is an increasingly common way to treat prostate cancer through localized radiation. The current standard of care relies on transrectal ultrasound (TRUS) for imaging…
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TLDR
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TLDR
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TLDR
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