Real time optical Biopsy: Time-resolved Fluorescence Spectroscopy instrumentation and validation

  title={Real time optical Biopsy: Time-resolved Fluorescence Spectroscopy instrumentation and validation},
  author={David S. Kittle and Fartash Vasefi and Chirag G. Patil and Adam N. Mamelak and Keith L. Black and Pramod V. Butte},
  journal={Scientific Reports},
The Time-resolved fluorescence spectroscopy (TR-FS) has the potential to differentiate tumor and normal tissue in real time during surgical excision. In this manuscript, we describe the design of a novel TR-FS device, along with preliminary data on detection accuracy for fluorophores in a mixture. The instrument is capable of near real-time fluorescence lifetime acquisition in multiple spectral bands and analysis. It is also able to recover fluorescence lifetime with sub-20ps accuracy as… Expand
8 Citations
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