Real-time multi-marker measurement of organic compounds in human breath: towards fingerprinting breath.

Abstract

The prospects for exploiting proton transfer reaction-time of flight-mass spectrometry (PTR-ToF-MS) in medical diagnostics are illustrated through a series of case studies. Measurements of acetone levels in the breath of 68 healthy people are presented along with a longitudinal study of a single person over a period of 1 month. The median acetone concentration across the population was 484 ppbV with a geometric standard deviation (GSD) of 1.6, whilst the average GSD during the single subject longtitudinal study was 1.5. An additional case study is presented which highlights the potential of PTR-ToF-MS in pharmacokinetic studies, based upon the analysis of online breath samples of a person following the consumption of ethanol. PTR-ToF-MS comes into its own when information across a wide mass range is required, particularly when such information must be gathered in a short time during a breathing cycle. To illustrate this property, multicomponent breath analysis in a small study of cystic fibrosis patients is detailed, which provides tentative evidence that online PTR-ToF-MS analysis of tidal breath can distinguish between active infection and non-infected patients.

DOI: 10.1088/1752-7155/7/1/017112

Cite this paper

@article{White2013RealtimeMM, title={Real-time multi-marker measurement of organic compounds in human breath: towards fingerprinting breath.}, author={Iain R. White and Kerry A Willis and Chris Whyte and Rebecca L Cordell and Robert S. Blake and A J Wardlaw and Satish K Rao and Jonathan Grigg and Andrew M Ellis and Paul S Monks}, journal={Journal of breath research}, year={2013}, volume={7 1}, pages={017112} }