Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse.

@article{Tymvios2008RealtimeMO,
  title={Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse.},
  author={Charalambos Tymvios and Sarah Jones and Christopher T. Moore and Simon C Pitchford and Clive P Page and Michael Emerson},
  journal={Thrombosis and haemostasis},
  year={2008},
  volume={99 2},
  pages={435-40}
}
Identifying and evaluating new therapeutic targets in platelets requires advanced animal models in which platelet responses can be measured directly and in situ. This is important because platelet function is strongly influenced by external factors such as those originating from the vascular endothelium. Our objectives were to record graded, non-lethal thromboembolic platelet responses to platelet agonists in situ in the mouse and to demonstrate an inhibitory effect of aspirin in our model… CONTINUE READING