Real-time measurement of dopamine release in rat brain

  title={Real-time measurement of dopamine release in rat brain},
  author={Werner G. Kuhr and R Mark Wightman},
  journal={Brain Research},
Dopamine release at the submicromolar level has been observed in the striatum of an anesthetized rat on a millisecond time scale. Fast-scan cyclic voltammetry with Nafion-coated microelectrodes has been synchronized with electrical stimulation of the medial forebrain bundle, and synaptic overflow is observed following a burst of 15 impulses. The rapid appearance of dopamine following this stimulus indicates that the source of dopamine is very close (approximately 10 micron) to the electrode… CONTINUE READING

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