Real-time kinetics of restriction–modification gene expression after entry into a new host cell

@inproceedings{Mruk2008RealtimeKO,
  title={Real-time kinetics of restriction–modification gene expression after entry into a new host cell},
  author={Iwona Mruk and R. M. Blumenthal},
  booktitle={Nucleic acids research},
  year={2008}
}
Most type II restriction-modification (R-M) systems produce separate restriction endonuclease (REase) and methyltransferase (MTase) proteins. After R-M system genes enter a new cell, protective MTase must appear before REase to avoid host chromosome cleavage. The basis for this apparent temporal regulation is not well understood. PvuII and some other R-M systems appear to achieve this delay by cotranscribing the REase gene with the gene for an autogenous transcription activator/repressor (the… CONTINUE READING
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