Real time investigation of protein folding, structure, and dynamics in living cells.

@article{Li2008RealTI,
  title={Real time investigation of protein folding, structure, and dynamics in living cells.},
  author={QianQian Li and Yuefei Huang and Nan Xiao and Victoria Lynn Murray and Jianglei Chen and Jianjun Wang},
  journal={Methods in cell biology},
  year={2008},
  volume={90},
  pages={287-325}
}
Real time investigation of protein folding, structure, and dynamics at high resolution in living cells, is the next major step in nano cell biology. However, there are a number of major hurdles that need to be overcome, such as coupled translation and folding, the intervention of chaperones and folding enzymes, translocation, export, and the targeting machinery, proteasomes and degradation signals, etc. Although some progress has been made in recent years (Royer, 2006), current technology… CONTINUE READING