Real-time intravital imaging of RGD-quantum dot binding to luminal endothelium in mouse tumor neovasculature.

@article{Smith2008RealtimeII,
  title={Real-time intravital imaging of RGD-quantum dot binding to luminal endothelium in mouse tumor neovasculature.},
  author={Bryan R. Smith and Zhen Cheng and Abhijit De and Ai Leen Koh and Robert Sinclair and Sanjiv Sam Gambhir},
  journal={Nano letters},
  year={2008},
  volume={8 9},
  pages={
          2599-606
        }
}
Nanoscale materials have increasingly become subject to intense investigation for use in cancer diagnosis and therapy. However, there is a fundamental dearth in cellular-level understanding of how nanoparticles interact within the tumor environment in living subjects. Adopting quantum dots (qdots) for their excellent brightness, photostability, monodispersity, and fluorescent yield, we link arginine-glycine-aspartic acid (RGD) peptides to target qdots specifically to newly formed/forming blood… CONTINUE READING

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