Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function.

Abstract

We investigated the roles of two Rab-family proteins, Rab3a and Rab5a, in hippocampal synaptic transmission using real-time fluorescence imaging. During synaptic activity, Rab3a dissociated from synaptic vesicles and dispersed into neighbouring axonal regions. Dispersion required calcium-dependent exocytosis and was complete before the entire vesicle pool… (More)

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@article{Star2005RealtimeIO, title={Real-time imaging of Rab3a and Rab5a reveals differential roles in presynaptic function.}, author={Erin N Star and A. Jamila. Newton and Venkatesh N. Murthy}, journal={The Journal of physiology}, year={2005}, volume={569 Pt 1}, pages={103-17} }