Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype.

@article{Stephens2010RealtimeGM,
  title={Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype.},
  author={Michelle Lee Stephens and François Pomerleau and Peter Huettl and Greg A. Gerhardt and Zhi-Ming Zhang},
  journal={Journal of neuroscience methods},
  year={2010},
  volume={185 2},
  pages={264-72}
}
Commonly used for research studies in the central nervous system, microdialysis has revealed a link between dysregulation of the excitatory neurotransmitter glutamate and ischemia and seizure, however limitations like slow temporal resolution have stalled the advancement of microdialysis as a diagnostic tool. We have developed and extensively characterized an enzyme-based microelectrode array technology for second-by-second in vivo amperometric measurements of glutamate in the mammalian CNS… CONTINUE READING
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