Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy.

@article{Lawrence2003RealtimeAO,
  title={Real-time analysis of the effects of cholesterol on lipid raft behavior using atomic force microscopy.},
  author={Jared C Lawrence and David E. Saslowsky and J Michael Edwardson and Robert M. Henderson},
  journal={Biophysical journal},
  year={2003},
  volume={84 3},
  pages={1827-32}
}
Cholesterol plays a crucial role in cell membranes, and has been implicated in the assembly and maintenance of sphingolipid-rich rafts. We have examined the cholesterol-dependence of model rafts (sphingomyelin-rich domains) in supported lipid monolayers and bilayers using atomic force microscopy. Sphingomyelin-rich domains were observed in lipid monolayers in the absence and presence of cholesterol, except at high cholesterol concentrations, when separate domains were suppressed. The effect of… CONTINUE READING

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