Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics

@inproceedings{Friedman2010RealtimeAO,
  title={Real-time analysis of T cell receptors in naive cells in vitro and in vivo reveals flexibility in synapse and signaling dynamics},
  author={Rachel S.C. Friedman and Peter Beemiller and Caitlin M. Sorensen and Jordan Jacobelli and Matthew F Krummel},
  booktitle={The Journal of experimental medicine},
  year={2010}
}
The real-time dynamics of the T cell receptor (TCR) reflect antigen detection and T cell signaling, providing valuable insight into the evolving events of the immune response. Despite considerable advances in studying TCR dynamics in simplified systems in vitro, live imaging of subcellular signaling complexes expressed at physiological densities in intact tissues has been challenging. In this study, we generated a transgenic mouse with a TCR fused to green fluorescent protein to provide insight… CONTINUE READING

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For imaging the OT-I–GFP TCR, samples

  • Bullen
  • 2009

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