Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices.

@article{Uchino2001RealtimeTV,
  title={Real-time, two-dimensional visualization of ischaemia-induced glutamate release from hippocampal slices.},
  author={Shigeo Uchino and Takeshi Nakamura and Kenji Nakamura and Sadayo Nakajima-Iijima and Masayoshi Mishina and Shinichi Kohsaka and Yoshihisa Kudo},
  journal={The European journal of neuroscience},
  year={2001},
  volume={13 4},
  pages={670-8}
}
The involvement of excitatory amino acid (EAA) toxicity in ischaemia-induced neuronal cell death has long been suggested. However, in the hippocampus, the brain site most vulnerable to ischaemia, the detailed spatial and temporal patterns of EAA release are not yet known. To address this issue, we have developed a novel strategy for the continuous, real-time, two-dimensional monitoring of EAA release from brain slices. As EAA detector, we used a cell line transformed with the N-methyl-D… CONTINUE READING