Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber.

  title={Real-time, contrast enhanced photoacoustic imaging of cancer in a mouse window chamber.},
  author={Ragnar Olafsson and Daniel R. Bauer and Leonardo G. Montilla and Russell S. Witte},
  journal={Optics express},
  volume={18 18},
A clinical ultrasound scanner and 14 MHz linear array collected real-time photoacoustic images (PAI) during an injection of gold nanorods (GNRs) near the region of a mature PC-3 prostate tumor in mice implanted with a skin flap window chamber. Three dimensional spectroscopic PAI (690-900 nm) was also performed to investigate absorption changes near the tumor and enhance specific detection of GNRs. Whereas GNRs improved PAI contrast (+18 dB), the photoacoustic spectrum was consistent with the… CONTINUE READING
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