Real-World Use of Apixaban for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis

@article{Proietti2018RealWorldUO,
  title={Real-World Use of Apixaban for Stroke Prevention in Atrial Fibrillation: A Systematic Review and Meta-Analysis},
  author={Marco Proietti and Imma Romanazzi and Giulio Francesco Romiti and Alessio Farcomeni and Gregory Y. H. Lip},
  journal={Stroke},
  year={2018},
  volume={49},
  pages={98–106}
}
Background and Purpose— The use of oral anticoagulant therapy for stroke prevention in atrial fibrillation has been transformed by the availability of the nonvitamin K antagonist oral anticoagulants. Real-world studies on the use of nonvitamin K antagonist oral anticoagulants would help elucidate their effectiveness and safety in daily clinical practice. Apixaban was the third nonvitamin K antagonist oral anticoagulants introduced to clinical practice, and increasing real-world studies have… Expand
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TLDR
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TLDR
In NVAF patients, NOACs were found to be more effective than warfarin at reducing stroke risk, and NOACSs also lowered the risk of all-cause mortality, cerebral hemorrhage, and severe bleeding inNVAF patients compared to warfar in real-world studies. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Estimated Effectiveness and Safety of Nonvitamin K Antagonist Oral Anticoagulants Compared With Optimally Acenocoumarol Anticoagulated "Real-World" in Patients With Atrial Fibrillation.
TLDR
In optimally acenocoumarol anticoagulated AF patients, estimated reductions in all clinical outcomes with various NOACs are evident, with the best effectiveness and safety profile with apixaban. Expand
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