Real-Time assessment of granule and tablet properties using in-line data from a high-shear granulation process.

@article{Luukkonen2008RealTimeAO,
  title={Real-Time assessment of granule and tablet properties using in-line data from a high-shear granulation process.},
  author={Pirjo Luukkonen and Magnus Fransson and Ingela Niklasson Bj{\"o}rn and Jaana Hautala and Bengt Lagerholm and Staffan Folestad},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 2},
  pages={950-9}
}
A method for real-time assessment of granule and tablet properties was investigated. A mixture of microcrystalline cellulose:mannitol:povidone (78.5:18.5:3) was used in the study and granulated with five different water amounts and two impeller speeds. This represents a full-factorial design with two factors, thus giving a causal structure to the variation between the experiments. Process data (power consumption, temperature and in-line near-infrared spectra) were collected during the… CONTINUE READING

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