Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish

@inproceedings{Palha2013RealTimeWV,
  title={Real-Time Whole-Body Visualization of Chikungunya Virus Infection and Host Interferon Response in Zebrafish},
  author={Nuno R. Palha and Florence Guivel-Benhassine and Val{\'e}rie Briolat and Georges Lutfalla and Marion Sourisseau and Felix Ellett and Chieh-Huei Wang and Graham J. Lieschke and Philippe Herbomel and Olivier Schwartz and J. -P. Levraud},
  booktitle={PLoS pathogens},
  year={2013}
}
Chikungunya Virus (CHIKV), a re-emerging arbovirus that may cause severe disease, constitutes an important public health problem. Herein we describe a novel CHIKV infection model in zebrafish, where viral spread was live-imaged in the whole body up to cellular resolution. Infected cells emerged in various organs in one principal wave with a median appearance time of ∼14 hours post infection. Timing of infected cell death was organ dependent, leading to a shift of CHIKV localization towards the… CONTINUE READING
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