Real-Time UV Imaging of Nicotine Release from Transdermal Patch

  title={Real-Time UV Imaging of Nicotine Release from Transdermal Patch},
  author={Jesper \Ostergaard and Emil Meng-Lund and Susan Weng Larsen and Claus Selch Larsen and Karsten Petersson and James Lenke and Henrik Nymann Jensen},
  journal={Pharmaceutical Research},
This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system. The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method. Calibration curves were successfully… CONTINUE READING
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