Real Time Fluorescence Imaging of Plcγ Translocation and Its Interaction with the Epidermal Growth Factor Receptor

@article{Matsuda2001RealTF,
  title={Real Time Fluorescence Imaging of Plcγ Translocation and Its Interaction with the Epidermal Growth Factor Receptor},
  author={Miho Matsuda and Hugh F. Paterson and Rosie Rodriguez and Amanda C. Fensome and Moira V. Ellis and Karl Swann and Matilda Katan},
  journal={The Journal of Cell Biology},
  year={2001},
  volume={153},
  pages={599 - 612}
}
The translocation of fluorescently tagged PLC gamma and requirements for this process in cells stimulated with EGF were analyzed using real time fluorescence microscopy applied for the first time to monitor growth factor receptor--effector interactions. The translocation of PLC gamma to the plasma membrane required the functional Src homology 2 domains and… CONTINUE READING