Reagents for astatination of biomolecules. 3. Comparison of closo-decaborate(2-) and closo-dodecaborate(2-) moieties as reactive groups for labeling with astatine-211.

@article{Wilbur2009ReagentsFA,
  title={Reagents for astatination of biomolecules. 3. Comparison of closo-decaborate(2-) and closo-dodecaborate(2-) moieties as reactive groups for labeling with astatine-211.},
  author={Daniel S Wilbur and M. F. Chyan and Donald K. Hamlin and Matthew A Perry},
  journal={Bioconjugate chemistry},
  year={2009},
  volume={20 3},
  pages={591-602}
}
In vivo deastatination has been a major problem in the development of reagents for therapeutic applications of the alpha-particle emitting radionuclide (211)At. Our prior studies demonstrated that the use of a closo-decaborate(2-) ([closo-B(10)H(9)R](2-)) moiety for (211)At labeling of biomolecules provides conjugates that are stable to in vivo… CONTINUE READING