Ready Access to 7 , 8-Dihydro-and 1 , 2 , 3 , 4-Tetrahydro-1311 1 , 6-Naphthyridine-5 ( 6 H )-ones from Simple Pyridine Precursors

@inproceedings{Showalter2006ReadyAT,
  title={Ready Access to 7 , 8-Dihydro-and 1 , 2 , 3 , 4-Tetrahydro-1311 1 , 6-Naphthyridine-5 ( 6 H )-ones from Simple Pyridine Precursors},
  author={Hollis D Showalter},
  year={2006}
}
Benzamides and nicotinamides represent classes of drugs that have experienced an unusually broad spectrum of clinical development in a number of therapeutic areas [1]. One of their principal targets is the nuclear DNAbinding protein poly(ADP-ribose) polymerase-1 (PARP1), which is activated by nicks in DNA during inflammation, ischemia, neurodegeneration, and cancer therapy. When over-activated, PARP can cause extensive polymerization of ADP-ribose, leading to the depletion of NAD and… CONTINUE READING