Readthrough suppression in the mammalian type C retroviruses and what it has taught us.

@article{Rein1992ReadthroughSI,
  title={Readthrough suppression in the mammalian type C retroviruses and what it has taught us.},
  author={Alan Rein and Judith G Levin},
  journal={The New biologist},
  year={1992},
  volume={4 4},
  pages={283-9}
}
Mammalian type C retroviruses use translational suppression to synthesize the enzymes which function in virus replication. The UAG termination codon at the end of the coding region for the viral core proteins is translated as glutamine at a frequency of approximately 5%, allowing synthesis of the enzymes as part of a large fusion protein. This unusual mechanism has several benefits for the virus: first, it modulates the relative levels of synthesis of the core proteins and the enzymes. This is… CONTINUE READING