Readministration of helper-dependent adenoviral vectors to mouse airway mediated via transient immunosuppression

@article{Cao2011ReadministrationOH,
  title={Readministration of helper-dependent adenoviral vectors to mouse airway mediated via transient immunosuppression},
  author={Huibi Cao and T Yang and X Li and J Wu and Cathleen Duan and Allan L. Coates and Jim Hu},
  journal={Gene Therapy},
  year={2011},
  volume={18},
  pages={173-181}
}
The efficacy of adenovirus-mediated gene therapy is attenuated by the host immune responses to both vector and transgene products. Even for helper-dependent adenoviral (HD-Ad) vectors, which have all viral-coding sequences deleted, the viral capsid proteins still cause immune reactions. In order to improve the efficiency in transgene expression during HD-Ad vector readministration, we administered cyclophosphamide to transiently modulate the mouse immune system. We delivered a high dose (5… CONTINUE READING
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