Reading the ubiquitin postal code.

  title={Reading the ubiquitin postal code.},
  author={J F Trempe},
  journal={Current opinion in structural biology},
  volume={21 6},
Polyubiquitin chains are assembled through the formation of an isopeptide bond between a lysine side-chain or terminal amino group of a proximal ubiquitin moiety and the carboxy-terminal of a distal ubiquitin moiety. Protein substrates tagged by polyubiquitin chains of different linkages undergo different fates. Many polyubiquitin chain types have been characterized so far, notably Lys11, Lys48, Lys63 and linear chains. These different types of chains are synthesized, disassembled and… CONTINUE READING

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