Reading of DNA sequence logos: prediction of major groove binding by information theory.

@article{Schneider1996ReadingOD,
  title={Reading of DNA sequence logos: prediction of major groove binding by information theory.},
  author={Thomas D. Schneider},
  journal={Methods in enzymology},
  year={1996},
  volume={274},
  pages={445-55}
}
DNA sequences to which the OxyR protein binds under oxidizing conditions were analyzed by the sequence logo method, a quantitative graphic technique based on information theory. A sequence logo shows both the sequence conservation and the frequencies of bases at each position in a site. Unlike the consensus sequence, the sequence logo analysis revealed that OxyR should bind to four major grooves of DNA. This was later confirmed by experiments. Detailed interpretation of the sequence logo also… CONTINUE READING