Reading between the LINEs: human genomic variation induced by LINE-1 retrotransposition.

@article{Sheen2000ReadingBT,
  title={Reading between the LINEs: human genomic variation induced by LINE-1 retrotransposition.},
  author={F. Sheen and S. Sherry and G. Risch and M. Robichaux and I. Nasidze and M. Stoneking and M. Batzer and G. Swergold},
  journal={Genome research},
  year={2000},
  volume={10 10},
  pages={
          1496-508
        }
}
The insertion of mobile elements into the genome represents a new class of genetic markers for the study of human evolution. Long interspersed elements (LINEs) have amplified to a copy number of about 100,000 over the last 100 million years of mammalian evolution and comprise approximately 15% of the human genome. The majority of LINE-1 (L1) elements within the human genome are 5' truncated copies of a few active L1 elements that are capable of retrotransposition. Some of the young L1 elements… Expand
136 Citations
Genomic characterization of recent human LINE-1 insertions: evidence supporting random insertion.
  • 117
  • PDF
Following the LINEs: an analysis of primate genomic variation at human-specific LINE-1 insertion sites.
  • 45
  • PDF
LINE-1 Retrotransposition Activity in Human Genomes
  • 460
  • Highly Influenced
LINE-1 preTa elements in the human genome.
  • 42
  • PDF
Allelic heterogeneity in LINE-1 retrotransposition activity.
  • 55
  • PDF
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 66 REFERENCES
African origin of human-specific polymorphic Alu insertions.
  • 321
  • PDF
A new retrotransposable human L1 element from the LRE2 locus on chromosome 1q produces a chimaeric insertion
  • 224
Alu repeats and human disease.
  • 858
  • PDF
Transduction of 3'-flanking sequences is common in L1 retrotransposition.
  • 229
  • PDF
L1 (LINE-1) retrotransposon evolution and amplification in recent human history.
  • 276
Alu insertion polymorphisms and human evolution: evidence for a larger population size in Africa.
  • 364
  • PDF
Ancestral, mammalian-wide subfamilies of LINE-1 repetitive sequences.
  • 359
Two additional potential retrotransposons isolated from a human L1 subfamily that contains an active retrotransposable element.
  • 106
  • PDF
...
1
2
3
4
5
...