Readers of poly(ADP-ribose): designed to be fit for purpose

  title={Readers of poly(ADP-ribose): designed to be fit for purpose},
  author={Federico Teloni and Matthias Altmeyer},
  booktitle={Nucleic acids research},
Post-translational modifications (PTMs) regulate many aspects of protein function and are indispensable for the spatio-temporal regulation of cellular processes. The proteome-wide identification of PTM targets has made significant progress in recent years, as has the characterization of their writers, readers, modifiers and erasers. One of the most elusive PTMs is poly(ADP-ribosyl)ation (PARylation), a nucleic acid-like PTM involved in chromatin dynamics, genome stability maintenance… CONTINUE READING
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