Reactogenicity and tolerability of a non-adjuvanted 11-valent diphtheria-tetanus toxoid pneumococcal conjugate vaccine in Filipino children.

@article{Ugpo2009ReactogenicityAT,
  title={Reactogenicity and tolerability of a non-adjuvanted 11-valent diphtheria-tetanus toxoid pneumococcal conjugate vaccine in Filipino children.},
  author={Juanita M Ugpo and Marilla Lucero and Gail M. Williams and Marites Lechago and Leilani Nillos and Veronica Tallo and Hanna Nohynek},
  journal={Vaccine},
  year={2009},
  volume={27 20},
  pages={2723-9}
}
In a phase three randomized, double-blind, saline-placebo controlled study conducted in Bohol, Philippines, we assessed the reactogenicity of an 11-valent PCV (11PCV) when given simultaneously with EPI vaccines at 6, 10 and 14 weeks of age in a subset of 252 and 126 children who were followed-up by passive and active surveillance, respectively. In passive surveillance (parents' observation), redness was observed in 14.4% vs. 11.8%, swelling in 8% vs. 3.9%, induration in 13.6% vs. 8.6%, and pain… CONTINUE READING